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There is no such thing as "Too big to fail!". That was a term that was coined by those special interests that didn't want to see banks fail. The reality is, banks have been failing for thousands of years, yet each and every day, the sun has risen in the morning and set in the evening.
That being said, I doubt very seriously if the German government will allow DB to fail (if they did, you would see banks stateside take a very big hit). Expect tax payer bail-ins as well as "some" bondholder losses.
The damage to Germany's, and the EU's economy will be quite consequential, and it would mark the opportunity for other regions and entities (ie. Asia) to climb up the food chain. The only problem is that when DB sneezes, Asia will catch the flu as well.